Figure 5. Enrichment analysis of METTL16 -related gene. (A) Protein–protein interaction network of METTL16 was performed via the STRING online resource. (B) Correlation of METTL16 and the top 5 genes (PRPF8, SPAG7, SENP3, GPS2 and ZNF638) in 33 types of cancer samples (C) The heat map of correlation between METTL16 and PRPF8, SPAG7, SENP3, GPS2 and ZNF638 in TCGA tumors. (D) GO|KEGG pathway analysis of the top 100 genes that associated with METTL16 expression.