Age, sex, and mitochondrial-haplotype influence gut microbiome composition and metabolites in a genetically diverse rat model

Hoang Van M. Nguyen; Eleana Cabello; David Dyer; Chloe Fender; Manuel Garcia-Jaramillo; Norman G. Hord; Steven Austad; Arlan Richardson; Archana Unnikrishnan

doi:doi:10.18632/aging.206211

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Research Paper Volume 17, Issue 2 pp 524—549

Age, sex, and mitochondrial-haplotype influence gut microbiome composition and metabolites in a genetically diverse rat model

Figure 3. Microbial species that are significantly changed with age are dependent on sex and mt-haplotype. Microbial species in the gut microbiome from male (A) or female (B) rats were compared for adult (9-months) and old (26-months), OKC-HET^B (blue boxes) and OKC-HET^W (red boxes) rats. The box plots display the 1st and 3rd quartiles with the horizontal line denoting the median, and the whiskers display minimum and maximum values. The data were collected from 6 to 10 rats per group and statistically compared using Mann-Whitney/Kruskal-Wallis and/or Linear Modeling with significance at ^*p < 0.05 or ^**p < 0.01 shown.