Research Paper Advance Articles
Fisetin ameliorates vascular smooth muscle cell calcification via DUSP1-dependent p38 MAPK inhibition
Figure 3. Effects of fisetin on calcification of VSMCs during pro-calcific conditions. Calcification detected by Osteosense fluorescence imaging (A) and normalized calcium content (n=6, B) in HAoSMCs treated for 11d with control (CTR) or calcification medium (Calc.) without and with 1 μM fisetin (Fis). Calcified areas: white pseudocolor. **(p<0.01), ***(p<0.001) significant vs. control group; †††(p<0.001) significant vs. Calc.-treated group.