Research Paper Volume 17, Issue 5 pp 1190—1205

Figure 1. Comparison between controls and progeroid syndrome patients. (A) Boxplots show significant telomere attrition in patients with progeroid syndromes (n = 57) compared to controls (n = 44), as indicated by the differences in DNAmTLAdjAge. Statistical significance was assessed using a two-tailed Wilcoxon rank-sum test (also known as Mann-Whitney U test) and represented by p-values. (B) Epigenetic age acceleration between controls (n = 44) and progeroid syndrome patients (n = 57): Boxplots with individual data points illustrate epigenetic age acceleration, measured using the GrimAge and PhenoAge clocks. Statistical significance was assessed using a two-tailed Student's t-test. All boxplots show the median represented as a line inside the box that represents the interquartile range (IQR), while whiskers extending from the box show the minimum and maximum.