Research Paper Volume 17, Issue 5 pp 1190—1205

Figure 4. Comparison of DNAmTLAdjAge across various protective groups. (A) Boxplots illustrate DNAmTLAdjAge across individuals carrying various protective variants. The control group (n = 41) represents individuals with the APOE ε3 allele, while the APOE group (n = 21) includes individuals with the APOE ε2 and APOE ε4 alleles. Sample sizes for the PCSK9 group and APOC3 group were n=9 and n = 6. Statistical significance was assessed using an ANOVA test. (B) The upper plot compares DNAmTLAdjAge between the different APOE allele groups (Neutral n = 41, Hralzheimer n = 10, Lralzheimer n = 21). The lower plot compares DNAmTLAdjAge between individuals carrying atherosclerosis protective variants (PCSK9 n = 9 and APOC3 n = 6) and 41 controls (with the APOE ε3 allele). Statistical significance was assessed using an ANOVA test.