Research Paper Volume 17, Issue 5 pp 1206—1220
Changes in metabolism-related RNA expression in circulating white blood cells of aged individual with physical frailty
Figure 10. Possible mechanism linking the metabolism of leukocyte and chronic inflammation. Without (A) and with (B) sufficient exercise. Gap junction-mediated cellular interactions decreased with aging which results in the increased glycolysis in WBC with hyperactivity. In contrast, exercise is known to activate de novo gap junction-mediated interaction that results in moderate glycolysis in WBC.