Research Paper Volume 17, Issue 5 pp 1206—1220
Changes in metabolism-related RNA expression in circulating white blood cells of aged individual with physical frailty
Figure 9. Schematic illustration of our hypothesis that links RNA transcription in WBC and physical frailty. Direct cell-cell interaction between circulating WBC and endothelium/satellite cells in healthy aged individuals decreases RNA transcription of metabolic-related genes in WBC while maintaining muscle function (A). In contrast, impaired cell-cell interactions result in no changes in the RNA transcription of metabolic-related genes in WBC, with impaired maintenance of muscle function (B).