Research Paper Volume 17, Issue 6 pp 1511—1520
rDNA copy number variation and methylation from birth to sexual maturity
Figure 1. UCE/CP methylation, absolute, and active CN in young individuals. (A) Mean methylation (Y axis) of the UCE/CP does not increase with age (X axis). Red dots represent blood samples of 139 healthy controls and blue dots of 141 individuals with DD. (B) UCE/CP methylation (Y axis) is significantly positively correlated with absolute rDNA CN (X axis). (C, D) Both the absolute number of rDNA TU (C) and active CN (D) remain stable during the first 20 years of life. There are no significant between-group differences.