Research Paper Volume 17, Issue 6 pp 1521—1543

Figure 1. (A) Plan of analysis for the current study. (B) Nested regression results from the HRS testing data including associations between TraMA and sociodemographic factors and health behaviors; points represent regression coefficients and bars represent 95% confidence intervals; all models include cell type and batch as covariates. Model 1 includes demographic factors; Model 2 includes variables in Model 1, as well as socioeconomic factors; Model 3 includes variables in Model 2, as well as health behaviors. (C) Regression results from the HRS testing data of health/aging outcomes on TraMA; points represent regression coefficients and bars represent 95% confidence intervals; all models include age, race/ethnicity, sex/gender, cell type, and batch as covariates. (D). Validation results from nested regression of time to death on TraMA in HRS and LLFS. Model 1 includes batch as a covariate; Model 2 includes batch, age, race/ethnicity, and sex/gender as covariates; Model 3 includes variables from Model 2, as well as RNA-based cell type as covariates.