Research Paper Advance Articles
Epigenetic age and accelerated aging phenotypes: a tumor biomarker for predicting colorectal cancer
Figure 2. Horvath’s clock: distribution of DNAmAge, AgeAccelDiff, and IEAA by selected CRC risk factors among CRC patients. (AgeAccelDiff, epigenetic age acceleration as departure of DNAmAge from chronological age; CRC, colorectal cancer; DNAmAge, DNA methylation–based marker of aging; IEAA, intrinsic epigenetic age acceleration as residuals adjusted for cell composition). (A) Alcohol (binary): DNAmAge; (B) Alcohol (binary): AgeAccelDiff; (C) Alcohol (binary): IEAA; (D) Alcohol (6 categories): DNAmAge; (E) Alcohol (6 categories): AgeAccelDiff; (F) Alcohol (6 categories): IEAA; (G) Oophorectomy: DNAmAge; (H) Oophorectomy: AgeAccelDiff; (I) Oophorectomy: IEAA.