Research Paper Advance Articles

Figure 3. Cancer-free probability curve of biological age by Healthy Eating Index-2015 whole fruit and vegetable intake and oophorectomy. (ACC, accelerated age (positive deviation of DNAm age from age); AgeAccelDiff, epigenetic age acceleration as departure of DNAmAge from chronological age; DCC, decelerated age (negative deviation of DNAm age from age); IEAA, intrinsic epigenetic age acceleration as residuals adjusted for cell composition). Healthy Eating Index-2015 whole fruits: (A) ≤ Mean, 4.10: Horvath’s clock, AgeAccelDiff; (B) > Mean, 4.10: Horvath’s clock, AgeAccelDiff; (C) ≤ Mean, 4.10: Levine’s clock, AgeAccelDiff; (D) > Mean, 4.10: Levine’s clock, AgeAccelDiff; (E) ≤ Mean, 4.10: Levine’s clock, IEAA; (F) > Mean, 4.10: Levine’s clock, IEAA. Healthy Eating Index-2015 vegetables: (G) ≤ Median, 4.23: Horvath’s clock, AgeAccelDiff; (H) > Median, 4.23: Horvath’s clock, AgeAccelDiff. Oophorectomy: (I) Never: Hannum’s clock, IEAA; (J) Both ovary removal: Hannum’s clock, IEAA.