Figure 4. Swimmer plots of definite HGPS. The period that was surveyed is indicated by a thick grey bar. The periods with missing clinical data are indicated by dotted lines. For Case 5, detailed information was available up to 2 years of age, but further clinical information was not available, except for death due to arrhythmia at 11 years of age. ◎ Start of lonafarnib treatment, ● Occurrence of dysglycemia, ■ Occurrence of dyslipidemia, ◆ Cardiovascular event, ▲ starting GH treatment, * Fatal event (death).