Second generation DNA methylation age predicts cognitive change in midlife: the moderating role of childhood socioeconomic status

Sophie A. Bell; Christopher R. Beam; Ebrahim Zandi; Alyssa Kam; Emily Andrews; Jonathan Becker; Deborah Finkel; Deborah W. Davis; Eric Turkheimer

doi:doi:10.18632/aging.206284

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Research Paper Volume 17, Issue 7 pp 1702—1720

Second generation DNA methylation age predicts cognitive change in midlife: the moderating role of childhood socioeconomic status

Figure 1. Path diagram depicting the association between DNAmAge and change in IQ, modified by childhood socioeconomic status (SES). Variances of ACE components are estimated, with paths to observed variables set to 1.0. All regression coefficients are unstandardized. b_A1 and b_C1 are regression coefficients from the A and C components of Childhood IQ to Adult IQ. b_P1 is the phenotypic regression conditional on b_A1 and b_C1. b_A2 and b_C2 are regression coefficients from the A and C components of Childhood IQ to DNAmAge. b_P2 is the phenotypic regression conditional on b_A2 and b_C2. b_A3 and b_C3 are regression coefficients from the A and C components of DNAmAge to Adult IQ. b_P3 is the phenotypic regression conditional on b_A3 and b_C3. SES is a covariate for DNAmAge and the IQ variables, and a moderator of b_P3.