Research Perspective Advance Articles
Age-related diseases as a testbed for anti-aging therapeutics: the case of idiopathic pulmonary fibrosis
Figure 3. Conceptual framework for aging alignment in disease models and therapeutic development. This schematic illustrates the spectrum of aging-related diseases (ARDs) based on their mechanistic overlap with fundamental aging processes. Based on our assessment, idiopathic pulmonary fibrosis (IPF) demonstrates the strongest aging alignment. This framework supports a bidirectional approach to therapeutic development: insights from aging biology inform disease-specific interventions, while clinical efficacy in high-alignment conditions like IPF provides validation feedback for potential geroprotective strategies. The therapeutic strategies shown (senolytics, telomere activation, TNIK inhibitors, epigenetic modulation, and metabolic regulation) represent promising approaches that may translate across multiple ARDs based on their promising results in IPF models and human patients.