Research Perspective Advance Articles
Analysis of the current state of frailty indexes and their implementation for aging intervention studies
Figure 1. Analysis of the frailty phenotype in 3-4, 18, and 28-month-old C57BL/6 mice. (A) Frailty index scores implemented using Parks et al., 2012 reference values. (A–i) Frailty index scores implemented using Whitehead et al., 2014 reference values. (A–ii) Frailty index scores using our own 3–4-month-old mice as reference values. (B) Grip strength (average forelimb parallel bar score) is normalized to weight for 3-4, 18, and 28-month-old mice. P-values ≤ 0.05 (*), ≤ 0.01 (**), ≤ 0.001 (***), ≤ 0.0001 (****) were calculated using one-way ANOVA for three or more independent groups or unpaired t-tests for just two independent groups. Columns represent the mean with error bars ± SD.