Research Paper Advance Articles
Bleomycin promotes cellular senescence and activation of the cGAS-STING pathway without direct effect on fibrosis in an idiopathic pulmonary fibrosis model
Figure 4. Viability was reduced after bleomycin treatment in PCLS from iUIP mice. (A, B) Relative viability was examined in PCLS from normal and iUIP treated with the vehicle or 1 μΜ bleomycin for 48 (A) or 120 h (B). Values were normalized to DNA content. (C, D) Ki67-positive cells in paraffin-embedded sections were stained and calculated based on the total number of cells. The results are shown as mean ± SE of five mouse PCLSs at each stage. Asterisks indicate *P < 0.05 and **P < 0.01 compared with the vehicle. “ns” is not statistically significant. Scale bars indicate 50 μm.