Research Paper Advance Articles

Figure 1. Aging-related changes in body weight, food intake, and PAI-1 mRNA levels in the gastrocnemius and soleus muscles of male and female mice. The figure shows the body weight (A), daily food intake (B), and PAI-1 mRNA levels in the gastrocnemius (C) and soleus (D) muscles of 6- and 24-month-old mice with PAI-1 gene deficiency (PAI-1^−/−) and their wild-type counterparts (PAI-1^+/+) (n = 9−10 in each group). Results of real-time PCR analysis for PAI-1 mRNA, expressed as a ratio to 18S rRNA, are shown. Plasma PAI-1 levels (E) in 6- and 24-month-old PAI-1^+/+ and PAI-1^−/− mice are shown (n = 10 in each group). Data are presented as mean ± standard error of the mean. ^**P < 0.01 and ^*P < 0.05.