Figure 2. Aging-related changes in muscle parameters in male and female mice. Lower limb muscle mass assessed using qCT (A), tissue weights of the gastrocnemius (B) and soleus (C) muscles, and grip strength (D) in 6- and 24-month-old mice with PAI-1 gene deficiency (PAI-1−/−) and their wild-type counterparts (PAI-1+/+) are shown (n = 10 in each group). Data are presented as mean ± standard error of the mean. **P < 0.01 and *P < 0.05.