Research Paper Advance Articles
Infusion of blood from young and old mice modulates amyloid pathology
Figure 1. Schematic representation of the blood infusion regime (blood from old and young wild type mice into Tg2576 mice). Wild-type mice aged 50–75 days (WT Young mice), and wild-type mice aged 443–532 days (WT Old mice) served as blood donors. This blood was transfused to 120-day-old Tg2576 mice, which then underwent to weekly transfusions and sacrificed at 363–366 days old. Before sacrificing, mice were evaluated for spatial memory. Postmortem analyses included immunopathological, biochemical, and proteomic evaluations of brain tissues.