Figure 8. Soleus muscle fiber cross-sectional area after the three-month intervention period. (A) Representative images of soleus (SOL) muscle histological sections stained for dystrophin for quantitation of myofibers. The scale bar represents 100 μm. (B) Quantitation of the total number of SOL myofibers. (C) Average SOL myofiber cross-sectional area (CSA). (D) The frequency distribution of SOL myofiber CSA. Inlay: Superimposed myofiber frequency distribution curves at 250 μm binning. ****p<0.0001, ***p<0.001, **p<0.01, *p<0.05, Two-way ANOVA with Bonferroni. n = 8 CTRL, n = 8 VWR, n = 8 CTRL+L-BAIBA, n = 8 VWR+L-BAIBA. Mean ± SD.