Research Paper Advance Articles

Figure 2. Striatal gene expression changes under SNCA overload largely occur in young TG rats. (A) Number of differentially expressed genes (DEGs) between experimental groups in the striatum, along the genotype (WT and TG) and age axes (5 and 12 months) and their interaction with the indicated significance cut-offs. (B) Heatmap of hierarchically clustered striatal expression changes relative to WT_5m of 2776 DEGs (union of striatal DEGs shown in Figure 2A) across experimental groups. (C) Average gene expression changes and standard deviation of all striatal DEGs plotted as centroids clustered in eight groups. Numbers of DEGs shown in brackets. (D) Five most significant enriched biological processes for the DEGs in cluster 6 with indicated adjusted p-value, enrichment ratio and DEG count in brackets. (E) Expression level for Gria2 as individual nRPKM data points across experimental groups with mean and standard error of the mean.