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• Research Paper Volume 12, Issue 5 pp 4283-4298

  Secondary injury to distal regions after intracerebral hemorrhage influence neurological functional outcome

  Relevance score: 6.690856

  Kangping Song, Xiaojie Liu, Qiuyue Zheng, Lingling Zhang, Hongying Zhang, Hailong Yu, Yan Zhu, Li-An Huang, Yingzhu Chen

  Keywords: 1H-MRS, cognitive functional outcome, DTI, ICH, motor functional outcome

  Published in Aging on March 8, 2020

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  Although many studies have focused on functional impairment after intracerebral hemorrhage, little is known about the relationship between secondary injuries to distal regions and neurological function. Our study aimed to evaluate the secondary injuries after intracerebral hemorrhage and explore their relationship to neurological functional outcome. Twenty-one patients with hemorrhages in supratentorial, deep locations and 10 healthy subjects were recruited. Longitudinal examinations of diffusion tensor imaging, hydrogen proton magnetic resonance spectroscopy imaging and neuropsychological assessment were performed after weeks 1 and 12 to elucidate the relationship between magnetic resonance imaging parameters and neurologic outcomes. By week 12, motor function had significantly improved, but cognitive function had deteriorated compared to week 1. Fractional anisotropy values for the ipsilateral cerebral peduncle correlated with motor function at week 1. No significant correlation between fractional anisotropy for the ipsilateral cerebral peduncle and the Fugl-Meyer Motor Scale was found at week 12. Fractional anisotropy values for the ipsilateral hippocampus were related to the Montreal Cognitive Assessment and Mini-Mental State Examination at weeks 1 and 12. Deep supratentorial hemorrhage may result in injury to distal regions, which correlate with impaired motor and cognitive function.

  

  Brain areas with decreased FA value at ICH patients at 1st w. Orange means the brain areas which FA value decreased compared with control group at1st w, Threshold=3.6594.

  
  
  

  

  Brain areas with decreased FA value of ICH patients at 12th w. Orange means brain areas with decreased FA value of ICH patients compared with control group at 12th w, Threshold=3.8495.

  
  
  

  

  Brain areas with decreased FA value of ICH patients at 1st w and 12th w. Brain areas with increased FA value (Orange) and decreased FA value (Blue) of ICH patients at 12th w compared with 1st w, Threshold=3.6335.

  
  
  

  

  ROIs analysis of FA value. *P<0.05, compared with control group; n.s P>0.05 compared with control group; # P<0.05, compared with 1st w; N.S P>0.05 compared with 1st w.

  
  
  

  

  ROIs analysis of MD value. n.s P>0.05 compared with control group; N.S P>0.05 compared with 1st w.

  
  
  

  

  Comparison of NAA/Cr between ICH group and control group. n.s P>0.05 compared with control group; N.S P>0.05 compared with 1st w.

  
  
  

  

  Baseline head CT of ICH patients immediately after admitting hospital.

  
  
  

• Research Paper Volume 11, Issue 11 pp 3876-3890

  Habitual tea drinking modulates brain efficiency: evidence from brain connectivity evaluation

  Relevance score: 6.3863716

  Junhua Li, Rafael Romero-Garcia, John Suckling, Lei Feng

  Keywords: tea drinking, brain efficiency, fMRI, DTI, default mode network, hemispheric asymmetry

  Published in Aging on June 14, 2019

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  The majority of tea studies have relied on neuropsychological measures, and much fewer on neuroimaging measures, especially for interregional connections. To date, there has been no exploration of the effect of tea on system-level brain networks. We recruited healthy older participants to two groups according to their history of tea drinking frequency and investigated both functional and structural networks to reveal the role of tea drinking on brain organization. The results showed that tea drinking gave rise to the more efficient structural organization, but had no significant beneficial effect on the global functional organization. The suppression of hemispheric asymmetry in the structural connectivity network was observed as a result of tea drinking. We did not observe any significant effects of tea drinking on the hemispheric asymmetry of the functional connectivity network. In addition, functional connectivity strength within the default mode network (DMN) was greater for the tea-drinking group, and coexistence of increasing and decreasing connective strengths was observed in the structural connectivity of the DMN. Our study offers the first evidence of the positive contribution of tea drinking to brain structure and suggests a protective effect on age-related decline in brain organisation.

  

  Comparisons of neuropsychological and cognitive measures between the tea drinking group (T) and non-tea drinking group (NT). A non-parametric permutation test was used to evaluate the significance level in group differences by permuting 10,000 times (* corrected p<0.05). Abbreviations: RAVLT_ir, Rey Auditory Verbal Learning Test with immediate recall; RAVLT_dr, Rey Auditory Verbal Learning Test with delayed recall; DigitSpan_fwd, forward Digit Span; DigitSpan_bwd, backward Digit Span; SDMT_written, Symbol Digit Modalities Test by written response; SDMT_oral, Symbol Digit Modalities Test by oral response; BostonNaming, Boston Naming Test; BlockDesign, Block Design tests from the Wechsler Adults Intelligence Scale (WAIS-III); CTT1, Color Trials Test 1; CTT2, Color Trials Test 2; MMSE, Mini-Mental State Examination, MoCA, Montreal Cognitive Assessment.

  
  
  

  

  Comparisons of global graph theoretical metrics between tea drinking (T) and non-tea drinking groups (NT). (A) Metrics computed on the functional connectivity network. (B) Metrics calculated on the structural connectivity network. Asterisks represent significance level obtained by permutation test (* corrected p< 0.05).

  
  
  

  

  Brain regions exhibiting significant differences in structural nodal efficiency between the tea drinking group and the non-tea drinking group at the significance level of 0.01 (uncorrected) statistical evaluated by a permutation test.

  
  
  

  

  Comparisons of hemispheric asymmetries of global graph theoretical metrics between the tea-drinking group (denoted by T) and the non-tea drinking group (denoted by NT). A positive value in the hemispheric asymmetry indicates the leftward hemispheric asymmetry while a negative value indicates the rightward hemispheric asymmetry. Asterisks represent significance level obtained by permutation test (* corrected p< 0.05). (A) Hemispheric asymmetries of global graph theoretical metrics for functional connectivity network. (B) Hemispheric asymmetries of global graph theoretical metrics for structural connectivity network.

  
  
  

  

  Connections with significantly different strengths between the tea drinking group and the non-tea drinking group within the default mode network. Significance was established by setting uncorrected p<0.05 with the permutation test. (A) Differences of connective strengths between the groups (tea drinking group minus non-tea drinking group) for significant connections in the functional network. (B) Differences of connective strengths between the groups for significant connections in the structural network.