Volume 17, Issue 4

29 April, 2025
pp 885—1076

About the Cover

The cover features Figure 1 " WRN is essential in maintaining metabolic, mitochondrial, and other longevity-related pathways as well as in inhibiting senescence in mesenchymal stem cells" from Lautrup et al.

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Research Papers

Fisetin ameliorates vascular smooth muscle cell calcification via DUSP1-dependent p38 MAPK inhibition

Mehdi Razazian, Sheyda Bahiraii, Azmat Sohail, Markus Mandl, Isratul Jannat, Georg Beilhack, Ioana Alesutan, Jakob Voelkl,

https://doi.org/10.18632/aging.206233 pp 885—907

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Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results

Mauricio Moel, Girish Harinath, Virginia Lee, Andy Nyquist, Stefanie L. Morgan, Anar Isman, Sajad Zalzala,

https://doi.org/10.18632/aging.206235 pp 908—936

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Decreased mitochondrial NAD+ in WRN deficient cells links to dysfunctional proliferation

Sofie Lautrup, Shi-Qi Zhang, Shinichiro Funayama, Lisa Lirussi, Tina Visnovska, Hoi-Hung Cheung, Marc Niere, Yuyao Tian, Hilde Loge Nilsen, Geir Selbæk, Janna Saarela, Yoshiro Maezawa, Koutaro Yokote, Per Nilsson, Wai-Yee Chan, Hisaya Kato, Mathias Ziegler, Vilhelm A. Bohr, Evandro F. Fang,

https://doi.org/10.18632/aging.206236 pp 937—959

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Pharmacological recapitulation of the lean phenotype induced by the lifespan-extending sulfur amino acid-restricted diet

Naidu B. Ommi, Dwight A.L. Mattocks, Karel Kalecký, Teodoro Bottiglieri, Sailendra N. Nichenametla,

https://doi.org/10.18632/aging.206237 pp 960—981

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Impact of Factor Xa inhibitors on cardiovascular events in older patients with nonvalvular atrial fibrillation

Masahiko Takahashi, Takeshi Morimoto, Ryu Tsushima, Yuya Sudo, Ai Sakamoto, Masahiro Sogo, Masatomo Ozaki, Keisuke Okawa,

https://doi.org/10.18632/aging.206238 pp 982—993

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Dietary associations with reduced epigenetic age: a secondary data analysis of the methylation diet and lifestyle study

Jamie L. Villanueva, Alexandra Adorno Vita, Heather Zwickey, Kara Fitzgerald, Romilly Hodges, Benjamin Zimmerman, Ryan Bradley,

https://doi.org/10.18632/aging.206240 pp 994—1010

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Examining frailty phenotypes of community-dwelling older adults in Taiwan using the falls risk for older people in the community – Taiwan version (Tw-FROP-Com)

Ya-Mei Tzeng, Senyeong Kao, Wun-Sin Chen, Shueh-Fen Chen, Shan-Ru Li, Yu-Lung Chiu, Yu-Tien Chang, Yaw-Wen Chang,

https://doi.org/10.18632/aging.206231 pp 1011—1025

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Mesenchymal stem cell-specific Sirt1 overexpression prevents sarcopenia induced by 1,25-dihydroxyvitamin D deficiency

Haiyun Chen, Biqi Ren, Jing Wang, Xingchen Liu, Xiangjiao Yi, David Goltzman, Dengshun Miao,

https://doi.org/10.18632/aging.206232 pp 1026—1042

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Comprehensive genomic characterization of programmed cell death-related genes to predict drug resistance and prognosis for patients with multiple myeloma

Yan Li, Fuxu Wang, Hongbo Zhao, Zhenwei Jia, Xiaoyan Liu, Guirong Cui, Tiejun Qin, Xiaoyang Kong,

https://doi.org/10.18632/aging.206234 pp 1043—1059

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Frailty predicts adverse clinical outcomes in patients with moderate to severe chronic kidney disease

Chiung-Ying Huang, Hsiao-Mei Tsao, Shu-Ling Liang, Tai-Shuan Lai, Yung-Ming Chen,

https://doi.org/10.18632/aging.206239 pp 1060—1072

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Correction

Correction 2 for: Taurine suppresses ROS-dependent autophagy via activating Akt/mTOR signaling pathway in calcium oxalate crystals-induced renal tubular epithelial cell injury

Yan Sun, Shiting Dai, Jin Tao, Yunlong Li, Ziqi He, Quan Liu, Jiawen Zhao, Yaoliang Deng, Juening Kang, Xuepei Zhang, Sixing Yang, Yunlong Liu,

https://doi.org/10.18632/aging.206246 pp 1073—1074

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Retraction

Retraction of: Glypican-1-targeted and gemcitabine-loaded liposomes enhance tumor-suppressing effect on pancreatic cancer

Yu Mu, Dezhi Wang, Liangyu Bie, Suxia Luo, Xiaoqian Mu, Yanqiu Zhao,

https://doi.org/10.18632/aging.206242 pp 1075—1076

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