Research Paper Advance Articles
Infusion of blood from young and old mice modulates amyloid pathology
- 1 Latin American Institute for Brain Health (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile
- 2 Center for Social and Cognitive Neuroscience (CSCN), School of Psychology, Universidad Adolfo Ibanez, Santiago, Chile
- 3 Department of Neurology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
- 4 Center for Integrative Biology (CIB), Universidad Mayor, Santiago, Chile
- 5 Division of Biotechnology, MELISA Institute, San Pedro de la Paz, Bio-Bio, Chile
- 6 Centro Integrativo de Biología y Química Aplicada (CIBQA), Universidad Bernardo O’Higgins, Santiago, Chile
Received: August 12, 2024 Accepted: July 30, 2025 Published: September 12, 2025
https://doi.org/10.18632/aging.206319How to Cite
Copyright: © 2025 Pizarro et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by the accumulation of misfolded proteins in the brain. Recently, the impact of blood components in the progression of this disease has come to attention. This study investigates the effects of infusing blood from young and old wild-type mice into transgenic mice that model AD brain amyloidosis. Impaired memory and Aβ accumulation were observed in mice infused with blood from old donors. A proteomic analysis in the brain of these mice identified alterations in components related to synaptogenesis and the endocannabinoid system. The α2δ2 protein, associated with neuronal calcium regulation, was validated as a possible mediator of the observed effects. This study highlights the influence of blood in AD pathology and the identification of potential therapeutic targets.